| 引用本文: | 高姗,宋鑫伟,彭诗雅,邓俊超,田旭,李瑞芳.线粒体核糖体蛋白基因中最末内含子与[]其他内含子间的相互作用[J].生物信息学,2025,23(2):152-164. |
| GAO Shan,SONG Xinwei,PENG Shiya,DENG Junchao,TIAN Xu,LI Ruifang.Interactions between the last introns and other introns in mitochondrialribosomal protein genes[J].Chinese Journal of Bioinformatics,2025,23(2):152-164. |
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| 摘要: |
| 前期相关研究表明,第一内含子与其它内含子之间的相互作用关系可能与基因表达调控密切有关。为探索最末内含子与其他内含子之间是否同样存在着相互作用？以线粒体核糖体蛋白基因序列为样本,计算每个基因序列的最末内含子与其他内含子反向互补序列之间的最佳匹配片段,并分析它们的特性,然后将这些特性和第一内含子与其它内含子之间相互作用的最佳匹配片段特性进行对比。结果发现,两种匹配片段的长度、GC含量、配对率等分布特征随物种总的变化趋势是一致的,但最佳匹配片段的相对位置分布有很大差异,说明第一内含子和最末内含子与其他内含子的相互作用存在着一定差异,意味着它们在相互作用基本元件结构方面具有保守性,而在基因表达调控作用方面可能具有差异性。 |
| 关键词: 局域比对 最末内含子 最佳匹配片段 线粒体核糖体蛋白 相互作用 |
| DOI：10.12113/202310014 |
| 分类号:Q61 |
| 文献标识码:A |
| 基金项目: |
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| Interactions between the last introns and other introns in mitochondrialribosomal protein genes |
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GAO Shan,SONG Xinwei,PENG Shiya,DENG Junchao,TIAN Xu,LI Ruifang
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(Department of Physics and Electronic Information, Inner Mongolia Normal University, Hohhot 010022, China)
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| Abstract: |
| Previous related researches have shown that the interaction relationship between the first intron and other introns may be closely related to the regulation of gene expression.In order to discovery if is there the same interaction between the final intron and other introns? In this work, the sequences of mitochondrial ribosomal protein genes were selected as the samples, the optimal matched segments between the last intron and the reverse complementary sequences of other introns of each gene were obtained, and the characteristics of the optimal matched segments were analyzed, and these characteristics with the characteristics of the optimal matched for interactions between the first introns and other introns were compared. It was found that the distributional characteristics of the length, GC content, and matching rate of the two kinds of optimal matched segments had the same trend with the five species, but the relative position frequencies of the optimal matched segments have very distinct different, it means the first intron and the last intron interacted with the other introns with some differences, implying that they were conserved in terms of the structure of the basic elements of the interactions, whereas they might be differentiated in terms of the roles of the regulation of gene expression. |
| Key words: Local matched alignment Last intron Optimal matched segments Mitochondrial ribosomal protein genes Interaction |
