| 引用本文: | 刘炳霄,杨林.CD36调控脂质代谢作用及机制[J].生物信息学,2023,21(2):86-95. |
| LIU Bingxiao,YANG Lin.Mechanism and function of CD36 in the regulation of lipid metabolism[J].Chinese Journal of Bioinformatics,2023,21(2):86-95. |
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| 摘要: |
| 脂质代谢是机体的重要代谢过程,其紊乱会导致众多疾病的发生。人类白细胞分化抗原36(cluster of differentiation 36,CD36)是一种在单核细胞、巨噬细胞、平滑肌细胞以及脂肪细胞高度表达的清道夫受体,是识别氧化低密度脂蛋白及长链脂肪酸的主要受体和转运蛋白,在脂质代谢过程中发挥着重要作用。本文综述了CD36基因及蛋白的结构和生理功能,阐述了清道夫受体CD36在脂质代谢过程中发挥的作用,并系统地总结了其级联AMPK、mTOR和MAPK信号通路参与脂质代谢过程的分子机制,为相关生物学研究提供了理论基础。 |
| 关键词: 脂质代谢 清道夫受体 CD36 |
| DOI：10.12113/202205003 |
| 分类号:Q51 |
| 文献标识码:A |
| 基金项目:国家自然科学基金项目(No. 31371755). |
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| Mechanism and function of CD36 in the regulation of lipid metabolism |
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LIU Bingxiao, YANG Lin
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(School of Chemical Engineering and Chemistry, Harbin Institute of Technology,Harbin 150001, China)
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| Abstract: |
| Lipid metabolism is an important metabolic process of the body, and its disorder will lead to many diseases. Cluster of differentiation 36 (CD36) is a scavenger receptor highly expressed in monocytes, macrophages, smooth muscle cells and adipocytes. It is the main receptor and transporter for the recognition of oxidized low-density lipoprotein or long-chain fatty acids. So it plays an important role in the process of lipid metabolism. The review recapitulates the update and current advances on the structure and function of CD36 gene and protein, expounds the role of CD36 in the process of lipid metabolism, and systematically summarizes the molecular mechanism that CD36 cascade AMPK, mTOR and MAPK signaling pathways to participate in the process of lipid metabolism, providing a theoretical basis for the relevant biological research. |
| Key words: Lipid metabolism Scavenger receptor CD36 |
