| 摘要: |
| 基于前期危险因子与生命机体机制信息相关互动图,探索危险因子与生命机体机制信息间所属功能位置关系和内在联系,将该互动图从二维形式提升到三维形式,构建出生命信息安全控制太极经纬图。该图由5个太极纬平面和1个垂直贯穿太极纬平面的生命信息安全控制轴组成,控制轴与太极纬平面间构成虚与实、经与纬关系,形成“致虚极,守静笃”的动态平衡局面。5个太极纬平面分别代表模式识别受体识别病原体相关分子模式和损伤相关分子模式、NK细胞活化受体识别机制、特异性识别系统机制、正负反馈性调控机制以及黏膜、皮肤与共生微生物相互联系机制。由太极纬平面间内在功能联系分析:第1、2太极纬平面机制处在整个系统最前沿位置,应对危险原发生第一响应,把危险原信息传递给第3太极纬平面；第3太极纬平面接受危险原信息,发生第二响应,处在“后援位置”；第4太极纬平面针对信息应答过度或不足作适时调整,作正、负反馈性功效,在整体系统中处于极其重要效应作用地位；第5太极纬平面机制是整个系统的基盘,特别是黏膜系统,该安全控制系统重点布局集中在此,体现在功能力量对比中巨量共生微生物客观存在决定其重要作用地位。由太极经纬图显示,NK细胞活化受体-配体关系中的配体归入该系统范畴中。首次提出“危险原”概念,涵盖抗原、病原体相关分子模式、损伤相关分子模式和NK细胞活化受体-配体(变应信息)的配体。还推出NK细胞功能效应机制原理假说:以物种整体遗传信息为背景,构筑决定攻击与否防控性配套受体-配体关系,推测细胞基因组中存在表达代表自身身份信息配体的基因家族和表达报告变应信息配体的基因家族。上述构建的太极经纬图显示出生命信息安全控制机制的整体构象。 |
| 关键词: 生命信息 安全控制 太极经纬图 三维结构 解构 危险原 |
| DOI：10.12113/202105011 |
| 分类号:S852.42 |
| 文献标识码:A |
| 基金项目:国家自然科学基金项目(No.30560107). |
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| Structure analysis of life information security control by Tai Chi mapping of theodolite |
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CHEN Nanhui, SONG Deping
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(School of Animal Science and Technology, Jiangxi Agricultural University, Nanchang 330045, China)
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| Abstract: |
| The functional affiliation and inner relationships between the risk factors and the mechanism of living organisms were analyzed based on the relevant interactive diagrams drawn from the analysis of the information characteristics of the risk factors and the mechanism of living organisms. The two-dimensional relevant interactive diagrams were upgraded to a three-dimensional diagram, which constructs the life information security control by Tai Chi mapping of theodolite. The Tai Chi mapping of theodolite is composed of five Tai Chi latitude planes, and a life information security control axis that runs through the center of the five Tai Chi latitude planes. The control axis and the Tai Chi latitude planes form the relationship of abstract and real and the relationship of longitude and latitude, which forms a situation of “attain the utmost in passivity, hold firm to the basis of quietude”, that is, a state of dynamic balance. The five Tai Chi latitude planes represent pattern recognition receptors to recognize pathogen-related molecular patterns and damage-related molecular patterns, NK cell activation receptor recognition mechanism, specific recognition system mechanism, positive and negative feedback regulation mechanism, and the interaction mechanism of mucosa, skin, and symbiotic microorganisms. Intrinsic functional linkage analysis showed that the first and second Tai Chi latitude plane mechanisms were at the forefront of the entire system, which had the first response to the dangergen, and the dangergen information was transmitted to the third Tai Chi latitude plane; the third Tai Chi latitude plane accepted the dangergen information and generated a second response, in the “backup position”; the fourth Tai Chi latitude plane made timely adjustments for excessive or insufficient information response, and performed positive and negative feedback functions,which played an extremely important role in the overall system; the fifth Tai Chi latitude plane mechanism was the foundation of the entire safety control system, especially the mucosal system. The key layout of the safety control system was concentrated in the fifth plane. The large amount of symbiotic microorganisms embodied in the layout of functional forces determines its important role. The Tai Chi mapping of theodolite showed that the ligands in the NK cell activation receptor(receptor for answeringstress-response information)-ligand(stress-response information) relationships are included in the system.The concept of “dangergen” was firstly proposed,which covers traditional antigens,pathogen-related molecular patterns,damage-related molecular patterns and the ligands in the NK cell activation receptor-ligand.The hypothesis of the principle of NK cell function effect mechanism was also proposed: on the basis of the overall genetic information of the species, the relationship between the supporting receptors and ligands that determines whether to attack or not was constructed, and it was speculated that there were gene families in the cell genome that express ligands representing their own identity information. and those express reporter allergenic information ligands.The constructed Tai Chi mapping of theodolite shows the overall conformation of the life information security control mechanism. |
| Key words: Life information Security control Tai Chi mapping of theodolite Three-dimensional structure Structure analysis Dangergen |
