| 引用本文: | 王琮,赵健,宋晓峰.真核生物环形RNA编码蛋白的研究进展[J].生物信息学,2020,18(1):1-7. |
| WANG Cong,ZHAO Jian,SONG Xiaofeng.Review on circular RNA with protein-coding ability in eukaryotes[J].Chinese Journal of Bioinformatics,2020,18(1):1-7. |
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| 摘要: |
| 环形RNA是一类广泛存在于真核细胞的内源性RNA,其由前体RNA反向剪接形成,呈闭环结构,没有5’端帽子结构及3’端polyA尾巴。一直以来,环形RNA被认为没有编码能力,不能编码蛋白质,只是作为microRNA“海绵”等方式,发挥调控功能。然而,近年来随着对环形RNA研究的不断深入,部分环形RNA被发现可通过非帽依赖翻译起始机制编码蛋白质。并且,环形RNA编码的蛋白质被证实在多个细胞过程中发挥着至关重要的作用。对目前环形RNA编码蛋白的研究现状进行综述,并对目前环形RNA编码蛋白的相关生物信息学工具进行了总结。 |
| 关键词: 环形RNA 编码潜能 内部核糖体进入位点 m6A甲基化修饰 |
| DOI：10.12113/201910002 |
| 分类号:Q74 |
| 文献标识码:A |
| 基金项目:国家自然科学基金项目(No.61973155,No.61571223) |
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| Review on circular RNA with protein-coding ability in eukaryotes |
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WANG Cong, ZHAO Jian, SONG Xiaofeng
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(College of Automation Engineering, Nanjing University of Aeronautics and Astronautics, Nanjing 210006, China)
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| Abstract: |
| Circular RNA (circRNA) is a type of endogenous RNA widely expressed in eukaryotic cells, which is formed by back-splicing of pre-RNA without 5cap and 3tail. circRNA has long been considered to be without coding ability, for it cannot encode protein and just regulates gene expression as microRNA sponge. However, with more and more research results on circRNA over the years, a small number of circRNAs has been proved able to encode protein or peptides in cap-independent manner. These proteins or peptide have been shown to play a vital role in cellular processes. This paper reviews the current circRNA research, and summarizes some bioinformatics methods related to circRNA protein coding ability. |
| Key words: circRNA Coding potential Internal ribosome entry site m6A modification |
