| 引用本文: | 郭亚茹,丰继华,于华峥,牟锦,黄月月,刘珂.基于遗传算法酵母核小体定位性质预测[J].生物信息学,2019,17(2):95-101. |
| GUO Yaru,FENG Jihua,YU Huazheng,MOU Jin,HUANG Yueyue,LIU Ke.Prediction of the location properties of yeast nucleosomes based on genetic algorithm[J].Chinese Journal of Bioinformatics,2019,17(2):95-101. |
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| 摘要: |
| 在DNA序列上,定位模糊的特殊核小体与定位良好的普通核小体同时存在于染色体区域内,但由于二者的化学性质差异不明显,区分较为困难。本文针对实验核小体在真核基因转录起始位点周围的分布规律和保守性建立了一个核小体分布模型,并在前人所做的预测核小体位置的工作基础上,利用遗传算法寻找模型上不同性质核小体的分布中心,构建核小体定位性质判别准则,最终确定了转录起始位点上、下游定位良好和模糊核小体的位置。 |
| 关键词: 核小体定位 酵母 分布模型 遗传算法 |
| DOI：10.12113/j.issn.1672-5565.201812001 |
| 分类号:Q343.1+7 |
| 文献标识码:A |
| 基金项目:国家自然科学基金项目(31160234). |
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| Prediction of the location properties of yeast nucleosomes based on genetic algorithm |
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GUO Yaru, FENG Jihua, YU Huazheng, MOU Jin, HUANG Yueyue, LIU Ke
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(School of Electrical and Information Engineering, Yunnan University for Nationalities, Kunming 650504,China)
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| Abstract: |
| In the DNA sequence, the special nucleosomes with localized ambiguity and the well-located common nucleosomes exist in the chromosomal region at the same time. However, since the chemical differences between the two are not obvious, it is difficult to distinguish them. In this paper, a nucleosome localization property prediction model is established for the distribution and conservation of experimental nucleosomes around the transcription initiation site of eukaryotic genes. On the basis of the previous work of predicting the location of nucleosomes, the genetic algorithm was used to find the distribution center of different nucleosomes on the model, and the karyotype localization property criterion was constructed. Finally, the position of the upstream and downstream of the transcription start site and the location of the fuzzy nucleosome were determined. |
| Key words: Nucleosome localization Yeast Distribution model Genetic algorithm |
