| 引用本文: | 赵苒,高振洪,卢卫红.空间环境对秀丽线虫行为及生长发育研究进展[J].生物信息学,2016,14(4):230-234. |
| ZHAO Ran,GAO Zhenhong,LU Weihong.Review on behavior and development of Caenorhabditiselegansin space environment[J].Chinese Journal of Bioinformatics,2016,14(4):230-234. |
|
| 摘要: |
| 与秀丽线虫有关的研究开始于20世纪60年代,秀丽线虫作为模式生物是第一个完成基因测序的多细胞生物,普遍应用于各种环境对生理和行为学研究中。空间环境以微重力、强辐射作为特点,对秀丽线虫的生理及行为产生很大影响。本文总结了微重力和辐射引起秀丽线虫运动能力、寿命、能量代谢等方面基因表达变化的研究成果。秀丽线虫与人类的序列相似性高达40%,空间环境对秀丽线虫行为及生长发育的研究为空间环境对人类健康影响研究提供数据支持,也为空间损伤修复研究提供理论基础。 |
| 关键词: 空间环境 微重力 辐射 秀丽线虫 生物学效应 |
| DOI：10.3969/j.issn.1672-5565.2016.04.06 |
| 分类号:Q693 |
| 文献标识码:A |
| 基金项目:2013年哈尔滨市学科带头人项目(No.2013RFXXJ042)；航天预先研究项目(No.040102)；航天预先研究项目 (No.01-1-08). |
|
| Review on behavior and development of Caenorhabditiselegansin space environment |
|
ZHAO Ran1, GAO Zhenhong1, LU Weihong1,2
|
|
(1.School of Chemistry and Chemcial Engineering, Harbin Institute of Technology, Harbin 150090,China; 2.Institute of Extreme Environmental Nutrition and Protection, Harbin 150090,China)
|
| Abstract: |
| The research related to C.elegansbegan from the 1960s. It’s the first multicellular organisms with sequenced genome. As a model organism , C.elegansis widely used in physiological and behavioral researches about environmental changes. Microgravity and strong radiation are two characteristics of space environment which has a significant impact on the growth and development of C.elegans. We sum up the result of the research related to the growth and development of C.elegansand the results of the behavior, life-span and expression changes of several proteins in simulated microgravity and radiation environment. C.eleganscan respond to environmental change very quickly, so it is common biological material used in the space environment study. According to the previous study, C.eleganshad a sequence similarity of 40% with human, and the research on the behavior and the development of C.elegansprovide data support for human’s health and theoretical foundation for space damage repair. |
| Key words: Space environment Microgravity Radiation C.elegans Biological effect |
