| 引用本文: | 郭仲莉,王永红,付晓.miR-21的高表达与胰腺癌预后关系的meta分析[J].生物信息学,2016,14(4):226-229. |
| GUO Zhongli,WANG Yonghong,FU Xiao.Meta analysis of the relationship between overexpression of miR-21 and prognosis in patients with pancreatic cancer[J].Chinese Journal of Bioinformatics,2016,14(4):226-229. |
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| 摘要: |
| 为评价miR-21的高表达与胰腺癌预后的相关性,通过全面检索PubMed, EMBASE, Google scholar,维普,CNKI等数据库,收集已公开发表的关于miR-21的高表达与胰腺癌预后相关性的文献,按meta分析的要求对原始文献的质量进行评估,采用STATA V12.0软件对各研究的效应量进行统计分析。结果发现共纳入4篇文献(共300个病例),合并总生存率(OS)HR为1.26 (95%CI:1.08~1.47,P<0.05)。由此可以推断胰腺癌预后的一个危险因素为miR-21的高表达。 |
| 关键词: meta分析 胰腺癌 miR-21 高表达 |
| DOI：10.3969/j.issn.1672-5565.2016.04.05 |
| 分类号:Q344+.13 |
| 文献标识码:A |
| 基金项目: |
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| Meta analysis of the relationship between overexpression of miR-21 and prognosis in patients with pancreatic cancer |
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GUO Zhongli ,WANG Yonghong ,FU Xiao
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(Department of laboratory,Chongqing Qianjiang Central Hospital, Chongqing 409000,China)
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| Abstract: |
| To evaluate the correlation between the overexpression of miR-21 and the prognosis of pancreatic cancer, we search of PubMed, EMBASE, Google, scholar, VIP, CNKI database, which has been published on the overexpression of miR-21 and prognosis of pancreatic cancer related literature, the quality of the original documents evaluation according to the requirements of meta analysis, statistical analysis is performed using STATA V12.0 software to study the effect of the amount of. Results show a total of 4 articles (300 cases) are included, and the overall survival rate (OS) HR is 1.26 (95%CI:1.08-1.47, P<0.05). We draw conclusions that a risk factor for the prognosis of pancreatic cancer is high expression of miR-21. |
| Key words: Meta analysis Pancreatic cancer miR-21 Overexpression |
