| 摘要: |
| 建立生命信息安全控制原理的理论性平台,由该平台的视野分析免疫学所涉及的诸多理论问题,譬如免疫记忆、免疫功能等方面,并针对性进行归纳以及绘制出相关图形,试图将免疫学理论中所呈现的纷繁复杂性的方面以及过于分散的条块更加条理化、清晰化及整体化。由逻辑学的层面讨论免疫学学名的形成,分析结果:免疫学学名应归结为主观是非逻辑意识产物,并主张认识论应回归自然生成逻辑的观点。免疫记忆在本质上是对遗传信息的记忆,离开了遗传信息的识别与分析就不存在免疫记忆。众多学者的系列研究资料表明,CD4+T细胞在CD8+T细胞反应的起始就辅助其发挥作用,并维持其记忆细胞功能,而CD4+T细胞的记忆是由TCR-MHCⅡ信号所决定。X线晶体衍射及三维结构图所显示MHCII类肽结合凹槽内的多肽更能显示出呈递多肽遗传信息的功能,而MHCI类分子肽结合凹槽内的多肽难以与呈递多肽遗传信息的功能联系起来。只有辅助性T细胞是决定与辅助记忆的细胞,其不仅决定B细胞胸腺依赖性抗原的记忆,而且决定CD8+T细胞的记忆性。对生命信息识别从记忆属性层面进行分类,即分为遗传信息密码识别(记忆属性)和非遗传信息密码识别(非记忆属性)2大类。通过危险因素、生命信息感应器、信息识别及应答调控这样4个相连贯环节的分析,绘制出生命信息安全控制原理图。从功能效应层面进行讨论,将生命信息安全控制的功效分类为正面功能效应和负面功能效应2大类,其中将组织修复归结为正面功能效应,创伤引起的无菌性炎症归结为负面功能效应。绘制出生命信息安全控制功效图,并讨论了生命信息安全控制功效图的建立在理论方面的重要意义。 |
| 关键词: 免疫学 学名 逻辑 免疫记忆 生命信息安全控制 原理图 功能效应图 |
| DOI：10.3969/j.issn.1672-5565.2016.01.09 |
| 分类号:Q-06 |
| 文献标识码:A |
| 基金项目:国家自然科学基金资助项目(30560107)。 |
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| Re-discussion on the life information security control theory |
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SONG Deping, CHEN Nanhui
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(College of Animal Science and Technology,Jiangxi Agricultural University,Nanchang 330045,China)
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| Abstract: |
| In this study, we attempt to establish the theoretical platform on life information security control theory, and analyze multiple theoretical subjects, such as immunological memory and function, related to immunology by using this platform. Sketch-maps were drawn in attempt to methodize, distinguish and integrate the complicated immune theories based on induction. When discussing the formation of the scientific name of immunology at the logical level, the scientific name of immunology should be the subjective products of logic consciousness, and the epistemology on immunology needs to follow the logic of natural formation. The innate character of immunological memory is the memory of genetic information, and the memory would not exist without the recognition and analysis of genetic information. Basing on analyses on the research results from many investigators, the CD4+T cell assists CD8+T cell cellular immunity and helps keep the immunological memory. While the immunological memory of CD4+T cell was determined by signals of TCR-MHC class. Results from the X-ray crystal diffraction and three dimensional structure indicated the polypeptide in binding groove of the MHC class II molecules have more function in delivering genetic information, while its hard to relate delivery function to MHC class II molecules. Its concluded that the T helper cells (Th cells) were the only lymphocytes determining and assisting the immunological memory.Th cells not only decide the memory of thymus dependent antigen of B cells, but also the memory of CD8+T cells. At the level of memory property, the recognition of life information can be divided into two types:genetic information code recognition (mnemonic property) and non-genetic information code recognition (non-mnemonic property). Based on the analysis on the four consistent links, danger factors, life information sensors, information recognition and response regulation, an elementary diagram was constructed. While at the level of functional effects, it can be divided into positive functional effects and negative functional effects. Of which, tissue repair should be regarded as the positive functional effect and the aseprtic inflammation caused by trauma should be consider as negative functional effect. So, we drew a functional effect diagram of life information security control and discussed the importance of development of that diagram on theory. |
| Key words: Immunology Scientific name Logic Immunological memory Life information security control theory Elementary diagram Functional effect schema |
