| 引用本文: | 韩九强,吕红强,刘俊,张善新.基于生物信息学的HERV研究现状与发展趋势[J].生物信息学,2014,12(02):117-122. |
| HAN Jiuqiang,L Hongqiang,LIU Jun,ZHANG Shanxin.Bioinformatics research and development of HERV[J].Chinese Journal of Bioinformatics,2014,12(02):117-122. |
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| 摘要: |
| 近年来研究证实,人内源性逆转录病毒(HERV)中长末端重复序列(LTR)和囊膜蛋白基因(env)与基因异常表达关系密切。本文阐述了HERV国内外研究现状与发展动态。从生物信息学角度对LTR中启动子、多聚腺苷化 (PolyA) 信号和增强子等顺式作用元件以及env中的免疫抑制区(ISD)进行了重点分析。指出上述元件和潜在功能区在基因的异常表达和囊膜蛋白的免疫抑制中起关键作用,必将成为HERV与基因异常表达关系研究的热点与趋势。通过此类研究,以期为癌症疾病的早期诊断和治疗靶位点的选择奠定理论基础。 |
| 关键词: 人内源性逆转录病毒 长末端重复序列 启动子 多聚腺苷化信号 免疫抑制区 |
| DOI：10.3969/j.issn.1672-5565.2014-02.20140207 |
| 分类号:TP183 |
| 基金项目: |
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| Bioinformatics research and development of HERV |
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HAN Jiuqiang, L Hongqiang, LIU Jun, ZHANG Shanxin
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(School of Electronic and Information Engineering, Xi’an Jiaotong University, Xi’an 710049, China )
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| Abstract: |
| Recent studies have confirmed that long terminal repeats (LTR) and the envelope gene (env) of human endogenous retroviruses (HERV) are closely related to aberrant gene expression. In this paper, the situations and development trends of domestic and foreign research on HERV were elaborated. The promoter, polyadenylation(PolyA) signal, enhancer and other cis-acting elements of LTR as well as immunosuppressive domain (ISD) of envin HERV were analyzed in the perspective of bioinformatics. It was suggested that the elements and potential functional domain, which play important roles in the abnormal gene expression and immunosuppression of envelope proteins, will become the focuses and trends of future research on the relationship between HERV and abnormal gene expression. It is hoped that these studies will be helpful to theoretical foundation for early diagnosis and selection of treatment target site of cancer. |
| Key words: Human endogenous retroviruses Long terminal repeats Promoter Polyadenylation signal Immunosuppressive domain |
