| 引用本文: | 吴琼,汪玉兰,赵健,宋晓峰.癌症中lncRNA调控可变剪接的生物信息学研究进展[J].生物信息学,2024,22(4):239-251. |
| WU Qiong,WANG Yulan,ZHAO Jian,SONG Xiaofeng.Bioinformatics advances of lncRNA regulated alternative splicing in cancer[J].Chinese Journal of Bioinformatics,2024,22(4):239-251. |
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| 摘要: |
| 可变剪接是指基因在不同剪接模式下生成RNA异构体的过程,是基因转录后表达调控的重要机制。可变剪接已被证实在癌症发生发展中扮演着重要角色,而异常剪接被认为是肿瘤发生的重要标志。长链非编码RNA(lncRNA)是基因可变剪接过程中的重要参与者和调节者,并且诸多证据表明lncRNA可通过调控可变剪接进而影响癌症的发生发展。本文对癌症中lncRNA调控的可变剪接相关研究进行了综述,并对相关生物信息学工具及数据库进行了总结。 |
| 关键词: lncRNA 可变剪接 剪接因子 癌症 生信工具 |
| DOI：10.12113/202303015 |
| 分类号:Q811.4 |
| 文献标识码:A |
| 基金项目:江苏省重点研发计划项目(No. BE2022843)；国家自然科学基金项目(No. 5,5,61973155). |
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| Bioinformatics advances of lncRNA regulated alternative splicing in cancer |
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WU Qiong,WANG Yulan,ZHAO Jian,SONG Xiaofeng
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(College of Automation Engineering, Nanjing University of Aeronautics and Astronautics, Nanjing 211106, China)
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| Abstract: |
| Alternative splicing refers to the process that genes produce RNA isoforms under different splicing modes, and it is an important mechanism for post-transcriptional expression regulation of genes. Alternative splicing has been proved to play an important role in the occurrence and development of cancer, and abnormal splicing is considered as an important symbol of tumor occurrence. Long noncoding RNA (lncRNA) is an important participant and regulator in the process of gene alternative splicing, and many evidences show that lncRNA can affect the occurrence and development of cancer by regulating alternative splicing. In this paper, the research on alternative splicing regulated by lncRNA in cancer is reviewed, and the related bioinformatics tools and databases are summarized. |
| Key words: IncRNA Alternative splicing Splicing factor Cancer Bioinformatics tools |
