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主管单位 工业和信息化部 主办单位 哈尔滨工业大学 主编 任南琪 国际刊号ISSN 1672-5565 国内刊号CN 23-1513/Q

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引用本文:张义定,雷锦志.异质性干细胞增殖过程中的熵变化[J].生物信息学,2024,22(1):58-69.
ZHANG Yiding,LEI Jinzhi.Entropy changes during the proliferation of heterogeneous stem cells[J].Chinese Journal of Bioinformatics,2024,22(1):58-69.
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异质性干细胞增殖过程中的熵变化
张义定1,雷锦志2
(1.天津工业大学 计算机科学与技术学院,天津 300387;2.天津工业大学 数学科学学院 应用数学中心,天津 300387)
摘要:
干细胞在多细胞生物体内广泛存在,其增殖过程在生命体的生长、发育、衰老、组织修复过程中起着重要作用。正常组织中的细胞增殖过程受到严格的控制,干细胞的异常增殖与恶性肿瘤、肥胖症、再生障碍性贫血等疾病有密切关系。生命体内异质性细胞的增殖过程是复杂的动力系统行为,干细胞异常增殖过程伴随细胞的可塑性变化和细胞间相互作用的再平衡过程,如何对这一过程进行定量描述是重要的研究课题。本文构建包含细胞的增殖分化指标和异常增殖性指标异质性的干细胞增殖模型,通过所建立的模型研究由于微环境变化引起的细胞异常增殖过程的熵变化,建立不同增殖条件下的系统熵变化与宏观动力学和系统参数之间的关系。结果表明,在细胞微环境变化引起异常增殖和恢复的过程中,系统的熵与细胞数量之间存在对应关系,而与微环境变化的路径无关。 此外,熵对细胞数量的依赖关系在异常增殖和恢复阶段表现出不同的行为,显示了生物过程的微观不可逆性。本文从物理学的角度对细胞异常增殖过程中熵变化与细胞数量变化的动力学给出定量刻画,为定量描述异质性干细胞增殖过程给出新的研究思路。
关键词:  干细胞增殖    肿瘤演变动力学  细胞异质性
DOI:10.12113/202205007
分类号:Q65
文献标识码:A
基金项目:国家自然科学基金项目(No.11831015).
Entropy changes during the proliferation of heterogeneous stem cells
ZHANG Yiding1, LEI Jinzhi2
(1.School of Computer Science and Technology, Tiangong University, Tianjin 300384, China;2. School of Mathematical Sciences, Tiangong University, Tianjin 300384, China)
Abstract:
Adult stem cells are found throughout the body and play an important role in tissue growth, development, aging, and wound healing. Stem cell regenerations are tightly regulated in normal tissues. Abnormal stem cell regeneration is closely associated with many diseases such as malignant tumors, obesity, aplastic anemia, etc. Heterogenous stem cell regeneration within living organisms is a complex dynamical system behavior. The abnormal cell proliferation includes processes of establishing a new balance along with cell plasticity and cell-to-cell interactions. It is a significant research topic to quantitatively describe the biological process of abnormal cell growth. This paper establishes a computational model of stem cell regeneration that incorporates proliferation and differentiation indicators of cells, as well as indicators of abnormal proliferation heterogeneity. Through the established model, the process of microenvironment changes-induced abnormal cell growth and the entropy evolution dynamics are studied. Moreover. the relationship between entropy dynamics and kinetic parameters under different proliferation conditions. Results show that during abnormal cell growth induced by microenvironmental changes, there exists a correspondence between entropy and the number of cells, which is independent of the pathway of microenvironmental changes. In addition, the dependence of entropy on cell number shows different behaviors during the abnormal proliferation and the recovery process, which suggests the irreversibility of the microscopic biological process. This paper presents a quantitative characterization of the entropy changes during abnormal cell growth through a physics perspective. It provides a new research approach for quantitative studies of the heterogeneous stem cell regeneration process.
Key words:  Stem cell proliferation  Entropy  Cancer evolution dynamics  Cell heterogeneity

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