| 引用本文: | 轩依然,赵健,宋晓峰.IRES介导的非帽依赖翻译调控研究进展[J].生物信息学,2024,22(1):1-10. |
| XUAN Yiran,ZHAO Jian,SONG Xiaofeng.Review on IRES-mediated cap-independent translation regulation[J].Chinese Journal of Bioinformatics,2024,22(1):1-10. |
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| 摘要: |
| 内部核糖体进入位点(Internal ribosome entry site, IRES)是一种存在于RNA内部的特殊功能元件,其可在不依赖5’端帽子结构的情况下直接招募核糖体启动蛋白翻译,已被发现与多种细胞过程密切相关。近来,越来越多的证据表明IRES在环形RNA翻译调控中扮演着极其重要的角色,由此IRES引起人们的极大关注。本文针对目前真核细胞中IRES介导的翻译调控机制进行了综述,并对IRES元件相关生物信息学工具进行了总结。 |
| 关键词: 内部核糖体进入位点 非帽依赖翻译 反式作用因子 G-四链体 上游开放阅读框 |
| DOI：10.12113/202207001 |
| 分类号:R318.04 |
| 文献标识码:A |
| 基金项目:国家自然科学基金项目(No.5,5,61973155)；江苏省重点研发计划项目(No.BE2022843)；中国博士后科学基金项目(No.2019M661817). |
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| Review on IRES-mediated cap-independent translation regulation |
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XUAN Yiran,ZHAO Jian,SONG Xiaofeng
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(College of Automation Engineering, Nanjing University of Aeronautics and Astronautics, Nanjing 211106, China)
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| Abstract: |
| Internal ribosome entry site (IRES) is a special functional element in RNA, which can directly recruit ribosome to initiate protein translation independently of the 5’ end cap structure. It has been found to be closely related to a variety of cell processes. Recently, IRES have attracted a lot of attention due to increasing evidence that they play an extremely important role in the regulation of circular RNA translation. This paper reviews the current mechanism of IRES-mediated translation regulation in eukaryotic cells, and summarizes the bioinformatics tools related to IRES elements. |
| Key words: Internal ribosome entry site Cap-independent translation ITAF G-quadruplex uORF |
