| 引用本文: | 李鑫,杨佳欣,张慧,何崇圣,赵小英.m6A修饰在植物生长发育和抗逆境胁迫中的功能[J].生物信息学,2023,21(1):29-36. |
| LI Xin,YANG Jiaxin,ZHANG Hui,HE Chongsheng,ZHAO Xiaoying.Function of N6-methyladenosine in plant growth and development and stress resistance[J].Chinese Journal of Bioinformatics,2023,21(1):29-36. |
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| 摘要: |
| 真核生物mRNA存在多种甲基化修饰,其中N6-腺苷酸甲基化(N6-methyladenosine, m6A)修饰是最为常见的一种动态内部修饰。m6A是指RNA腺嘌呤的第6位氮原子上发生甲基化修饰,它能够动态的被甲基转移酶添加,被去甲基化酶去除,以及被甲基化阅读蛋白识别。近年来,植物m6A修饰相关的酶被陆续鉴定,研究发现m6A修饰调控植物胚胎发育、茎尖分生组织分化、开花等生长发育过程,在植物抗逆境胁迫响应中也具有重要调控作用。本文就m6A修饰相关酶的组成及其在植物生长发育和植物抗逆境胁迫过程中的功能相关研究进展进行综述,并对甘蓝型油菜中m6A修饰相关的酶进行了生物信息学分析。 |
| 关键词: m6A甲基化 甲基转移酶 去甲基化酶 甲基化阅读蛋白 植物生长发育 抗逆境胁迫 |
| DOI：10.12113/202108010 |
| 分类号:Q756 |
| 文献标识码:A |
| 基金项目:国家自然科学基金项目 (No. U20A2029); 长沙市科技计划项目 (kq1901028). |
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| Function of N6-methyladenosine in plant growth and development and stress resistance |
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LI Xin, YANG Jiaxin, ZHANG Hui, HE Chongsheng, ZHAO Xiaoying
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(Hunan Province Key Laboratory of Plant Functional Genomics and Developmental Regulation,Hunan Engineering and Technology Research Center of Hybrid Rapeseed,College of Biology,Hunan University,Changsha 410082, China, )
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| Abstract: |
| There are multiple methylation modifications in eukaryotic mRNA, among which the N6-adenotide methylation (N6-methyladenosine, m6A) modification is one of the most common dynamical internal modifications. m6A is the methylation modification that occurs on the sixth nitrogen atom of RNA adenine, which is able to be dynamically added by methyltransferases, removed by demethylases, and recognized by reading proteins. Recently, m6A methylase components in plant have been identified and found to play important roles in plant embryo development, shoot apical meristem proliferation, flowering, as well as stress resistance. This paper reviews the plant m6A methylase compositions and research progress of function of m6A in plant growth and development and stress resistance, and provides a bioinformatics analysis of m6A enzymes in Brassica napus. |
| Key words: N6-methyladenosine Methyltransferases Demethylases Reading proteins Plant growth and development Stress resistance |
