| 引用本文: | 苏绍玉,卢芷琳,史智凌,叶秀云,鄢仁祥.蛋白质酶功能分析和预测方法的进展和前瞻[J].生物信息学,2022,20(4):227-234. |
| SU Shaoyu,LU Zhilin,SHI Zhiling,YE Xiuyun,YAN Renxiang.Development and prospect of function analysis and prediction methods for protein enzymes[J].Chinese Journal of Bioinformatics,2022,20(4):227-234. |
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| 蛋白质酶功能分析和预测方法的进展和前瞻 |
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苏绍玉1,2,3,卢芷琳2,3,史智凌2,3,叶秀云2,3 ,鄢仁祥2,3
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(1.福建省科学技术信息研究所 福州 350003; 2.福建省海洋酶工程重点实验室,福州 350116; 3.福州大学 生物科学与工程学院,福州 350100)
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| 摘要: |
| 蛋白质酶是生物体内最重要的生物分子之一。对酶的功能进行系统研究具有重要的科学研究价值和工业应用意义,近年来,以计算机技术为基础的酶功能预测的方法不断发展与完善。基于此背景,本文总结了基于计算方法的酶功能分析与预测的主要方法,包括酶结合位点、分子对接、动力学模拟以及分子设计等内容。同时,本文也对相应的发展趋势进行讨论和展望。 |
| 关键词: 酶 功能分析 生物信息学 |
| DOI：10.12113/202105004 |
| 分类号:Q5；Q7 |
| 文献标识码:A |
| 基金项目:国家自然科学基金项目(2017R1008-10);福建省属公益类科研院所基本科研专项(No.31500673). |
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| Development and prospect of function analysis and prediction methods for protein enzymes |
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SU Shaoyu1,2,3, LU Zhilin2,3, SHI Zhiling2,3, YE Xiuyun2,3, YAN Renxiang2,3
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(1.Fujian Institute of Scientific and Technological Information, Fuzhou 350003, China; 2.Fujian Key Laboratory of Marine Enzyme Engineering, Fuzhou 350116, China;3.College of Biological Science and Engineering, Fuzhou University, Fuzhou 350100, China)
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| Abstract: |
| Enzymes are one of the most important biological molecules in organisms. Systematic study of the functions of enzymes is of great value to scientific research and industrial application. In recent years, the methods of enzyme function prediction based on computer technology have been developing and improving. Based on this context, this paper summarizes the main computational-based methods of enzyme function prediction, including the binding sites, molecular docking, dynamic simulation, and molecular design. Meanwhile, the developing trend is discussed and prospected in this paper. |
| Key words: Enzyme Function analysis Bioinformatics |
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