| 引用本文: | 刘婷婷,陈琪,苏敏,王蕾,张莎莎,杨帆,常福厚.AhR与Nrf2基因相互作用的分子机制研究进展[J].生物信息学,2022,20(1):1-10. |
| LIU Tingting,CHEN Qi,SU Min,WANG Lei,ZHANG Shasha,YANG Fan,CHANG Fuhou.Research progress of molecular mechanism of interaction between AhR and Nrf2 genes[J].Chinese Journal of Bioinformatics,2022,20(1):1-10. |
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| AhR与Nrf2基因相互作用的分子机制研究进展 |
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刘婷婷1,陈琪1,苏敏1,王蕾1,张莎莎1,杨帆1,常福厚1,2,3
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(1.内蒙古医科大学 药学院,呼和浩特 010000; 2.内蒙古自治区新药筛选工程研究中心,呼和浩特 010000; 3.内蒙古医科大学新药安全评价研究中心,呼和浩特 010000)
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| 摘要: |
| 芳香烃受体(Aryl hydrocarbon receptor, AhR)作为一种配体依赖性激活的转录因子,调控肿瘤细胞的生长、增殖和凋亡,对环境中毒物和异物质代谢、机体免疫调节具有重要作用。核因子E2-相关因子2(Nuclear factor erythroid 2-related factor 2, Nrf2)是氧化还原、代谢和蛋白质稳态的中枢调节因子,存在于多种信号级联放大(Signaling cascade)通路中。在机体的抗氧化应激防御系统里扮演着重要角色,具有抗炎、抗凋亡、抗增殖、保护心肌细胞等作用。AhR和Nrf2基因在肿瘤的发生、发展中都起到了重要的作用。AhR是苯并芘(Benzo[α]pyrene, BaP)等毒物产生毒性作用及氧化损伤的关键因子,Nrf2是机体抗氧化损伤的关键因子,二者存在相互拮抗的作用,但有时也存在相互激活的协同作用,本文针对以上内容就近年来国内外的研究进展作一综述,为AhR和Nrf2的在肿瘤和其他疾病中的作用机制的研究奠定一定基础。 |
| 关键词: 芳香烃受体(AhR) 核因子E2相关因子2(Nrf2) AhR/Nrf2相互作用 分子机制 |
| DOI：10.12113/202009011 |
| 分类号:R966 |
| 文献标识码:A |
| 基金项目: |
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| Research progress of molecular mechanism of interaction between AhR and Nrf2 genes |
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LIU Tingting1, CHEN Qi1, SU Min1, WANG Lei1, ZHANG Shasha1, YANG Fan1, CHANG Fuhou1,2,3
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(1.School of Pharmacy, Inner Mongolia Medical University, Hohhot 010000 China; 2.Inner Mongolia Autonomous Region Engineering Research Center of New Pharmaceutical Screening, Hohhot 010000, China; 3.New Drug Safety Evaluation Research Center, Inner Mongolia Medical University, Hohhot 010000,China)
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| Abstract: |
| Aryl hydrocarbon receptor (AhR) is a ligand-dependent activated transcription factor that regulates the growth, proliferation, and apoptosis of tumor cells, and plays an important role in the metabolism of environmental poisons and foreign substances as well as the immune regulation of the body. Nuclear factor erythroid 2-related factor 2 (Nrf2) is a central regulator of redox, metabolism, and protein homeostasis, existing in multiple signaling cascade pathways. It plays an important role in the anti-oxidative stress defense system of the body and has functions of anti-inflammatory, anti-apoptosis, anti-proliferation, and protection of myocardial cells. Both AhR and Nrf2 genes have vital impact on the occurrence and development of tumors. AhR is a key factor in the toxic effects and oxidative damage of benzo[α]pyrene (BaP) and other poisons. Nrf2 is a key factor in the anti-oxidative damage of the body. The two have antagonistic effects, but sometimes there is also a synergistic effect of mutual activation. This article reviews the research progress of the area at home and abroad over the past years, which lays certain foundation for the research on the mechanism of AhR and Nrf2 in tumors and other diseases. |
| Key words: Aryl hydrocarbon receptor (AhR) Nuclear factor E2-related factor 2 (Nrf2) AhR/Nrf2 interaction Molecular mechanism |
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