| 引用本文: | 黄晓妍,黎嘉琳,冀慎英,张湘豫,郭勇,邹先琼.糖脂转运蛋白家族新成员人类GLTPD2的生物信息学分析[J].生物信息学,2021,19(3):216-222. |
| HUANG Xiaoyan,LI Jialin,JI Shenying,ZHANG Xiangyu,GUO Yong,ZOU Xianqiong.Bioinformatics analysis of human GLTPD2, a new member of the glycolipid transfer protein family[J].Chinese Journal of Bioinformatics,2021,19(3):216-222. |
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| 糖脂转运蛋白家族新成员人类GLTPD2的生物信息学分析 |
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黄晓妍1,黎嘉琳1,冀慎英1,2,张湘豫1,2,郭勇1,邹先琼1,3
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(1.桂林医学院 生物技术学院, 桂林541100; 2.桂林医学院 基础医学院, 桂林541100; 3.桂林医学院 附属口腔医院, 桂林 541004)
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| 摘要: |
| 人类糖脂转运结构域2蛋白(Glycolipid transfer protein domain containing 2, GLTPD2)是糖脂转运蛋白(Glycolipid transfer protein, GLTP)家族的一个新成员,其功能目前尚不清楚。研究的目的在于通过生物信息学分析,预测人类GLTPD2的结构、功能及其在疾病发生发展中的作用。通过UCSC Genome Browser、Human Protein Atlas及STRING等在线生物信息学分析工具对人类GLTPD2基因及其蛋白进行分析,结果表明人类GLTPD2蛋白等电点为10.19,分子量为31.6 kDa,定位于囊泡的膜蛋白,在肝、肠、肾等组织中的表达较高,可能具有糖脂转运,参与基因转录、细胞增殖及分化等功能。为进一步深入研究人类GLTPD2的生物学功能及其在疾病发生发展中的作用提供了重要的理论基础和实验依据。 |
| 关键词: GLTPD2 糖脂转运蛋白 生物信息学分析 |
| DOI：10.12113/202004012 |
| 分类号:Q811.4 |
| 文献标识码:A |
| 基金项目:国家级大学生创新训练项目(No.201810601024)；国家自然科学基金项目(No.81760490). |
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| Bioinformatics analysis of human GLTPD2, a new member of the glycolipid transfer protein family |
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HUANG Xiaoyan1, LI Jialin1, JI Shenying1,2, ZHANG Xiangyu1,2, GUO Yong1, ZOU Xianqiong1,3
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(1. College of Biotechnology, Guilin Medical University, Guilin 541100,China; 2. College of Basic Medicine, Guilin Medical University, Guilin 541100, China;3. Affiliated Stomatology Hospital of Guilin Medical University, Guilin 541004,China)
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| Abstract: |
| Human glycolipid transfer protein domain containing 2 (GLTPD2) is a new member of the glycolipid transfer protein (GLTP) family, whose function is still unclear. The purpose of this study is to predict the structure and function of human GLTPD2 and its role in the initiation and progression of diseases through bioinformatics analysis. In this study, human GLTPD2and its protein were analyzed through online bioinformatics analysis tools such as UCSC Genome Browser, Human Protein Atlas, and STRING. Results show that human GLTPD2 was a 31.6-kDa membrane protein with an isoelectric point of 10.19 and located in the vesicles. Moreover, the human GLTPD2 was highly expressed in liver, intestine, kidney, and other tissues, and it might have the function of glycolipid transport, gene transcription, proliferation and differentiation, etc. The results of this study provide an important theoretical and experimental basis for the further study of the biological function of human GLTPD2 and its role in the initiation and progression of diseases. |
| Key words: GLTPD2 Glycolipid transfer protein Bioinformatics analysis |
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