| 引用本文: | 刘珂,丰继华,黄月月,郭亚茹,牟锦.基于希尔伯特-黄变换的核小体定位特征提取[J].生物信息学,2019,17(4):237-248. |
| LIU Ke,FENG Jihua,HUANG Yueyue,GUO Yaru,MOU Jin.Feature extraction of nucleosome localization based on Hilbert-Huang transform[J].Chinese Journal of Bioinformatics,2019,17(4):237-248. |
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| 摘要: |
| 核小体是染色体折叠的整体结构,它们的空间分布与基因组活动的调节密切相关,是基因工程和表观遗传的重要研究领域。为进一步研究核小体定位特征的物种间差异性,将希尔伯特-黄变换(HHT)引入到酵母和果蝇两个不同物种的定位信号中,从多个角度客观分析核小体定位信号特征在两个物种间的差异性。在此基础上,对酵母和果蝇核小体分布的周期特征和进化印记进行尺度和频域分析,结果表明酵母和果蝇染色体在组织结构上存在显著差异。本文研究思路为准确提取信号瞬时频率提供了前提条件。 |
| 关键词: 核小体 真核模式生物 希尔伯特-黄变换(HHT) 果蝇 酵母 |
| DOI：10.12113/j.issn.1672-5565.201905003 |
| 分类号:Q343.1+7 |
| 文献标识码:A |
| 基金项目:国家自然科学基金(No.31160234). |
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| Feature extraction of nucleosome localization based on Hilbert-Huang transform |
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LIU Ke, FENG Jihua, HUANG Yueyue, GUO Yaru, MOU Jin
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(School of Electrical and Information Engineering, Yunnan University for Nationalities, Kunming 650504, China)
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| Abstract: |
| Nucleosomes are the overall structure of chromosome folding, whose spatial distribution is closely related to the regulation of genomic activity. It is an important research field of genetic engineering and epigenetics. In order to further study the interspecies variability of nucleosome localization characteristics, Hilbert-Huang transform (HHT) was introduced into the localization model of two different species of yeast and Drosophila, and the nucleosome localization signal was objectively analyzed from multiple angles. The difference lied in the characteristics of the two species. On this basis, the scale and frequency domain analysis of the periodic characteristics and evolutionary imprints of yeast and Drosophila nucleosome distribution showed that there were significant differences in the tissue structure between yeast and Drosophila chromosomes. The research ideas in this paper provide preconditions for accurately extracting the instantaneous frequency of the model. |
| Key words: Nucleosome Eukaryotic model organism Hilbert-Huang transform (HHT) Drosophila Yeast |
