| 引用本文: | 肖航,冯平,周岐海.长寿与衰老相关分子机制研究进展[J].生物信息学,2019,17(4):195-206. |
| XIAO Hang,FENG Ping,ZHOU Qihai.Recent advances in molecular mechanisms related to longevity and aging[J].Chinese Journal of Bioinformatics,2019,17(4):195-206. |
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| 摘要: |
| 长寿是一个复杂的特征,因遗传、环境等因素的差异而不同,理想情况下主要取决于衰老速率。相关分子机制多种多样,主要有生长激素(GH)和胰岛素样生长因子1(IGF-1)途径、Forkhead box O3基因(FOXO3)、AMP活化蛋白激酶(AMPK)、sirtuins家族基因、载脂蛋白E基因(APOE)、端粒酶基因、mTOR信号通路、抑癌基因p53、慢性炎症转录因子NF-κB、自噬-溶酶体信号通路、长链非编码RNA(lncRNAs)、 蛋氨酸亚砜还原酶系统(Msr)。同时,环境因素也影响着人类的寿命,例如饮食限制、运动、地理条件、环境压力等。本文从遗传和环境两方面综述影响人类寿命因素的最新研究进展。 |
| 关键词: 长寿基因 衰老 遗传 寿命 |
| DOI：10.12113/j.issn.1672-5565.201901007 |
| 分类号:Q343.1 |
| 文献标识码:A |
| 基金项目:国家自然科学基金项目(No.31670400,No.31870514). |
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| Recent advances in molecular mechanisms related to longevity and aging |
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XIAO Hang, FENG Ping, ZHOU Qihai
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(Key Laboratory of Ecology of Rare and Endangered Species and Environmental Protection, Ministry of Education, Guangxi Normal University, Guilin 541004, Guangxi, China)
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| Abstract: |
| Longevity is a complex trait that varies depending on genetic, environmental, and other factors, while it mainly depends on the rate of aging under ideal conditions. There are various molecular mechanisms involved, including growth hormone (GH) and insulin-like growth factor 1 (IGF-1) pathway, Forkhead box O3 gene (FOXO3), AMP-activated protein kinase (AMPK), sirtuins family gene, apolipoprotein. E gene (APOE), telomerase gene, mTOR signaling pathway, tumor suppressor gene p53,chronic inflammatory transcription factor NF-κB, autophagy-lysosomal signaling pathway, long noncoding RNAs (lncRNAs), and methionine sulfoxide reductase system (Msr). At the same time, environmental factors also affect the life expectancy of human beings, such as dietary restrictions, exercise, geographical conditions, environmental pressures, and so on. This paper reviews the latest research progress on factors affecting human life expectancy from the aspects of genetics and environment. |
| Key words: Longevity genes Aging Inheritance Life expectancy |
