| 摘要: |
| 基因表达谱芯片和核酸序列数据在癌症研究中占有很重要的地位。基因表达谱芯片被广泛的应用在医学研究中,它的主要优势在于灵敏快速成本低,缺点只能对现有基因进行研究,无法进行新基因发现以及变异等方面的研究；而核酸序列数据在这方面则具有很大优势。总体来说,二者在癌症研究中都发挥着巨大的作用。随着精准医学的不断发展,对这些高通量数据的深入研究可以有助于人们进一步了解癌症的分子机制,从而加速个体化治疗的进程。 |
| 关键词: 芯片 高通量测序 癌症 生物信息学 |
| DOI：10.12113/j.issn.1672-5565.201810002 |
| 分类号:Q343.1 |
| 文献标识码:A |
| 基金项目:国家自然科学基金青年项目 (No.81402175). * |
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| Applications of microarray and high-throughput sequencing in cancer research: current state and perspectives |
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CHEN Yongzi
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(Department of Cancer Cell Biology, Tianjin Medical University Cancer Institute and Hospital,Tianjin Medical University Cancer Institute and Hospital, Key Laboratory of Cancer Prevention and Therapy,Tianjins Clinical Research Center for Cancer National Clinical Research Center for Cancer, Tianjin 300060, China)
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| Abstract: |
| Microarray data and sequencing data are two main types of high-throughput data in cancer related study. The most obvious advantages of microarray data are its sensitivity, rapid detection, and relatively low cost. Due to the fact that microarray data could only identify known genes instead of novel genes and variants, sequencing data have been involved in a lot of cancer mechanism studies. In general, both types of data are crucial in cancer research. Along with development of precision medicine, high-throughput data analysis can help people understand the mechanisms of cancer as well as expedite personalized cancer treatment. |
| Key words: Microarray High-throughput sequencing Cancer Bioinformatics |
