| 摘要: |
| 循环肿瘤细胞(CTCs)对恶性肿瘤传播转移有重要影响,因此CTCs识别技术的出现与不断进步有着重要的临床意义,准确可靠的CTCs识别技术将为尽早确诊肿瘤、指导个性化治疗方案、诊断微小残留病变以及评估抗癌药物的敏感性提供强有力的工具。本文针对核酸检测法、免疫细胞化学术、流式细胞术和基于表征特性图像识别技术等CTC识别技术的发展情况进行了综述总结,比较各种技术的优缺点,对现阶段该领域存在的问题进行了讨论,并对CTCs识别的技术发展方向作了进一步的展望,为学者们提供更广的研究思路。 |
| 关键词: 循环肿瘤细胞 恶性肿瘤 识别技术 |
| DOI：10.12113/j.issn.1672-5565.201801004 |
| 分类号:Q354 |
| 文献标识码:A |
| 基金项目: |
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| Research status of identification for circulating tumor cells |
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WANG Yan, XU Xiulin
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(School of Medical Instrument and Food Engineering, University of Shanghai for Science and Technology, Shanghai 200093, China)
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| Abstract: |
| Circulating tumor cells (CTCs) have an important effect on the process of malignant tumor metastasis. Therefore, the emergence and continuous progress of CTCs detection technology have important clinical significance. Accurate and reliable CTCs identification techniques provide a powerful tool for early diagnosis of cancer, guidance of personalized treatment options, diagnosis of minimal residual disease, and assessment of the sensitivity of anticancer drugs. This article reviews the development of CTC identification methods such as PCR, Immunocytochemistry, flow cytometry, and image recognition technology based on characterization, compares the advantages and disadvantages of each method, and makes further prospect on the development direction of CTCs identification, so as to provide a broader research direction for scholars. |
| Key words: Circulating tumor cell Malignant tumor Identification technique |
