| 摘要: |
| Nrf2是调控细胞氧化应激反应的重要转录因子,同时也是维持细胞内氧化还原稳态的中枢调节者。Nrf2通过诱导调控一系列抗氧化蛋白的组成型和诱导型表达,可以减轻活性氧和亲电体引起的细胞损伤,使细胞处于稳定状态,维持机体氧化还原动态平衡。本研究为了从分子层面深入探讨剖析Nrf2发挥抗氧化功能的作用机制,通过查找阅读大量相关文献并进行整理归纳,最终从Nrf2的结构与激活、Nrf2抗氧化功能以及Nrf2抗氧化的分子调控机制三个方面进行了概述分析。其中在对Nrf2抗氧化的分子调控机制的探讨部分,既探析了对Nrf2起激活作用的相关调节因子的作用机制,又分析了Nrf2被激活后对其下游多种抗氧化因子及谷胱甘肽氧化还原系统的诱导调控机制,以期较深入了解Nrf2抵抗机体氧化应激损伤作用及其抗氧化分子调控机制。 |
| 关键词: Nrf2 氧化应激 抗氧化 分子调控,机制 |
| DOI：10.3969/j.issn.1672-5565.201708001 |
| 分类号:Q753 |
| 文献标识码:A |
| 基金项目:国家自然科学基金项目(No.31371755). |
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| Molecular regulatory mechanism of Nrf2 antioxidant |
|
LI Hui, YANG Lin
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(School of Chemical Engineering and Chemistry, Harbin Institute of Technology, Harbin 150001, China)
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| Abstract: |
| Nrf2 is an important transcription factor that regulates the cellular oxidative stress responses and is also the central regulator in maintaining the intracellular redox homeostasis. Through the induction and regulation of the constitutive and inducible expression of a series of antioxidant proteins, Nrf2 can reduce the cell damage caused by reactive oxygen species and electrophiles, keep the cells in a stable state and maintain the redox dynamic equilibrium. To explore and analyze the functionary mechanism of Nrf2 antioxidant from the molecular level, we searched and read a large number of relevant literature and then summarized, and finally we conducted an overview analysis from three aspects of the structure and activation of Nrf2, the antioxidant function of Nrf2 and the molecular regulatory mechanism of Nrf2 antioxidant. Among them, in the part of investigating the molecular regulatory mechanism of Nrf2 antioxidant, we have explored the functionary mechanism of regulatory factors related with Nrf2 activation, and also have analyzed the inductive regulation mechanism of activated Nrf2 on its downstream various antioxidant factors and glutathione redox system who will be more in-depth understanding of the role and mechanism of Nrf2 in resisting oxidation stress injury in the body. |
| Key words: Nrf2 Oxidative stress Antioxidant Molecular regulation Mechanism |
