| 摘要: |
| 蛋白质二级结构是指蛋白质骨架结构中有规律重复的构象。由蛋白质原子坐标正确地指定蛋白质二级结构是分析蛋白质结构与功能的基础,二级结构的指定对于蛋白质分类、蛋白质功能模体的发现以及理解蛋白质折叠机制有着重要的作用。并且蛋白质二级结构信息广泛应用到蛋白质分子可视化、蛋白质比对以及蛋白质结构预测中。目前有超过20种蛋白质二级结构指定方法,这些方法大体可以分为两大类:基于氢键和基于几何,不同方法指定结果之间的差异较大。由于尚没有蛋白质二级结构指定方法的综述文献,因此,本文主要介绍和总结已有蛋白质二级结构指定方法。 |
| 关键词: 蛋白质二级结构指定 蛋白质结构 |
| DOI：10.3969/j.issn.1672-5565.2016.03.09 |
| 分类号:Q71 |
| 文献标识码:A |
| 基金项目: |
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| Protein secondary structure assignment |
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CAO Chen1, MA Kun2
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(1.College of Computer Science and Technology, Jilin University, Changchun 130012, China; 2.Jiangsu Hengrui Medicine Co., Ltd., Lianyungang Jiangsu 222047, China )
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| Abstract: |
| Secondary structure protein refers to regular repeative sub-structures on the protein backbone. The accurate assignment of the secondary structure of proteins from protein atom coordinates underlies the analysis of protein structure and function. It is also very important for protein classification, finding functional motifs in proteins, and understanding the folding mechanisms of proteins as well as for molecular visualization, protein comparison and prediction. Thus, protein secondary structure assignment is still an active research field in structural bioinformatics. More than twenty secondary structure assignment methods have been developed and are generally categorized into two groups, i.e.,geometry-based and hydrogen bond-based. However, the consistence of secondary structure assigned by different methods is relatively low. These is no review paper about protein secondary structure assignment so far.Therefore,this paper mainly introduce and summarize these methods. |
| Key words: Protein secondary structure assignment Protein structure |
