| 引用本文: | 李大鹏,鞠颖,廖之君,邹权.与肿瘤相关的计算microRNA组学研究综述[J].生物信息学,2015,13(4):225-230. |
| LI Dapeng,JU Ying,LIAO Zhijun,ZOU Quan.Review on computational microRNomics related to tumor research[J].Chinese Journal of Bioinformatics,2015,13(4):225-230. |
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| 与肿瘤相关的计算microRNA组学研究综述 |
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李大鹏1,鞠颖2,廖之君3,4,邹权3
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(1.秦皇岛市第四医院肿瘤内科,河北 秦皇岛 066000; 2.厦门大学计算机科学系,福建 厦门 361005; 3.天津大学计算机科学与技术学院,天津 300072; 4.福建医科大学生物化学与分子生物学系,福州 350108)
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| 摘要: |
| 癌症基因组学研究一直都是肿瘤遗传学研究的重要课题。目前已有许多研究致力于寻找与肿瘤相关的基因。而调控基因表达的miRNA在肿瘤基因组研究中还有很大的研究空间。本文从系统生物学的视角,综述了与肿瘤相关的致病miRNA寻找、表达差异和isomiR的研究现状；最后给出了对近期miRNA组学热点的评述和未来的研究方向。 |
| 关键词: 癌症 miRNA 系统生物学 生物网络 |
| DOI：10.3969/j.issn.1672-5565.2015.04.04 |
| 分类号:TP802 |
| 基金项目:国家自然科学基金(61370010);秦皇岛市科技支撑计划项目(NO.20152A217)。 |
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| Review on computational microRNomics related to tumor research |
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LI Dapeng 1, JU Ying2, LIAO Zhijun3,4, ZOU Quan 3
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(1. Department of Internal Medicine-Oncology,The Fourth Hospital in Qinhuangdao,Qinhuangdao,Qinhuangdao Hebei 066000,China;2. Department of Computer Science, Xiamen University, Xiamen Fujian 361005, China;3. School of Computer Science and Technology, Tianjin University, Tianjin 300072, China;4. Department of Biochemistry and Molecular Biology, Fujian Medical University, Fuzhou 350108, China)
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| Abstract: |
| Cancer genomics is an essential topic in the tumor genetics research. Lots of works have been done for identifying oncogenes. However, the regulatory miRNAs remains to be further studied.In this paper, we focused on onco-miRNAs, and reviewed the cancer related miRNA detection, expression and isomiRs from the view of system biology. Fimally we summarized the recent hot topics on microRNomics. |
| Key words: Cancer miRNA System biology Biological network |
